DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability?

Figure 1

This graph shows the most statistically significant pathways involved in methylation variations of gene promoters between early and late passages of hBM-MSCs, obtained by Ingenuity Pathway Analysis (IPA). Blue bars indicate −log(𝑃 value), while the orange squares indicate the ratio of input list genes that map to the considered pathway divided by the total number of genes involved in this specific pathway.