Adiponectin Deficiency Blunts Hypoxia-Induced Mobilization and Homing of Circulating Angiogenic Cells

Figure 1

PC number in blood and BM and influence of Adipoq ^−/− Different progenitor populations were investigated by flow cytometry. Compared to WT animals, the numbers of bone marrow-residing Sca-1⁺ and Lin⁻Sca-1⁺ subpopulations (expressed per 10⁵ cells, depicted on the left axis) were markedly diminished in Adipoq ^−/− conditions. Sca-1⁺ and Lin⁻Sca-1⁺ progenitors in the blood showed a similar trend. Additionally, the B/BM ratio (%, depicted on the right axis) was reduced for Sca-1⁺, which could indicate an additional mobilization deficit for Sca-1⁺ cells under Adipoq ^−/− conditions. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001; ns: not statistically significant; dots represent outliers.

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