Clinical Study

Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients

Table 2

Demographic characteristics of the pGBM patient.

CharacteristicsgCSCs positivegCSCs negative value*

Age (years)0.188
 Median
 Range11–7228–82
Sex (number [%])0.653
 Male8 (53%)11 (46%)
 Female7 (47%)13 (54%)
Mean follow-up (months)0.225
Pathological diagnosis Primary glioblastomaPrimary glioblastoma
TreatmentSurgery + Stupp’s regimen [19]Surgery + Stupp’s regimen [19]
Extent of surgery (number [%])
 Total resection10 (67%)14 (58%)0.636
 Subtotal resection 4 (27%)8 (33%)
 Partial resection1 (7%)2 (8%)
Recurrences (number [%])11 (73%)12 (50%)0.192
Treatment of recurrences (number [%])
 Radiation therapy1 (9%)0 (0%)
 Adjuvant temozolomide6 (55%)10 (83%)
 None4 (36%)2 (17%)
1p 19q codeletion by FISH1 (7%)0 (0%)0.385
MGMT methylation by PCR 7 (47%)11 (45%)1.000

pGBM: primary glioblastoma; gCSCs: glioma cancer stem cells; MGMT: O-6-methylguanine-DNA methyltransferase. By Mann-Whitney test for continuous variables and by Fisher’s exact test for categorical variables.