Stem Cells International / 2014 / Article / Tab 2 / Clinical Study
Prognostic Value of Glioma Cancer Stem Cell Isolation in Survival of Primary Glioblastoma Patients Table 2 Demographic characteristics of the pGBM patient.
Characteristics gCSCs positive gCSCs negative value* Age (years) 0.188 Median Range 11–72 28–82 Sex (number [%]) 0.653 Male 8 (53%) 11 (46%) Female 7 (47%) 13 (54%) Mean follow-up (months) 0.225 Pathological diagnosis Primary glioblastoma Primary glioblastoma Treatment Surgery + Stupp’s regimen [19 ] Surgery + Stupp’s regimen [19 ] Extent of surgery (number [%]) Total resection 10 (67%) 14 (58%) 0.636 Subtotal resection 4 (27%) 8 (33%) Partial resection 1 (7%) 2 (8%) Recurrences (number [%]) 11 (73%) 12 (50%) 0.192 Treatment of recurrences (number [%]) Radiation therapy 1 (9%) 0 (0%) Adjuvant temozolomide 6 (55%) 10 (83%) None 4 (36%) 2 (17%) 1p 19q codeletion by FISH 1 (7%) 0 (0%) 0.385 MGMT methylation by PCR 7 (47%) 11 (45%) 1.000
pGBM: primary glioblastoma; gCSCs: glioma cancer stem cells; MGMT: O-6-methylguanine-DNA methyltransferase. By Mann-Whitney test for continuous variables and by Fisher’s exact test for categorical variables.