Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model

Figure 2

Cell infiltrates in kidney grafts. Graft infiltrates of macrophages ((a): ED1), T-cells ((b): TCR), B-cells ((c): KiB1), and NK-cells ((d): 10/78) in the allo group compared to allo EV as cells per high power field. While macrophages were not different (a), T- and B- cells ((b), (c)) were significantly more frequent in kidneys from the allo EV group while NK-cells were reduced compared to allo (d).

(a) Macrophages (ED1)

(b) T-cells (TCR)

(c) B-cells (KiB1)

(d) NK-cells (1078)