Research Article
Accelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model
Figure 2
Differences in wound size following treatment with human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) and hESC-MSC-derived fibroblasts (hESC-MSC-Fbs) after three ischemia/reperfusion (I/R) cycles. The dorsal skin of mice was subjected to three I/R cycles and injected subcutaneously with phosphate-buffered saline (PBS), hESC-MSCs, or hESC-MSC-Fbs. (a) Representative images of wounds after treatment are shown on the indicated days after three I/R cycles. (b) Hematoxylin and eosin staining of dorsal skin on 12 and 15 days after three I/R cycles. (c) Wound size was determined on the indicated days after treatment (, two-way ANOVA; ).
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