Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Table 2

Involvement of HAT in normal development.

HAT	Organism	Impact on development	Ref
CBP	Null mice	Neural tube closure and embryonic vascular and cardiac defects	[35]
CBP	Mice harbouring point mutation or deletion of the HAT domain	Several defects in memory and synaptic plasticity	[37, 38]
CBP	Null mice	Rubinstein-Taybi syndrome (RTS) multilineage	[8]
p300	Heterozygous mice	Embryonic lethality	[35]
p300	Mice harbouring point mutation	Defects in the hematopoiesis (B-cell deficiency, megakaryocytosis, and thrombocytosis)	[39]
GCN5	Mice harbouring a point mutations abrogating GN5 HAT activity	Cranial neural tube closure defects and exencephaly	[41]
GCN5	Null mice	Early embryonic lethality	[40]
	Knockdown zebrafish	Cardiac, fin, and limb defects	[45]
pCAF	Null mice	Normal phenotype in the embryo	[42, 44]
		Defects in learning abilities and short-term and long-term memory in adult	[44]
	Knockdown zebrafish	Cardiac, fin, and limb defects	[45]
ATAT-1	Null mice	Viable, without morphological defects; loss of α-tubulin acetylation in sperm flagella; dentate gyrus distortion	[46]