Review Article
Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
Table 2
Involvement of HAT in normal development.
| HAT | Organism | Impact on development | Ref |
| CBP | Null mice | Neural tube closure and embryonic vascular and cardiac defects | [35] |
| CBP | Mice harbouring point mutation or deletion of the HAT domain | Several defects in memory and synaptic plasticity | [37, 38] |
| CBP | Null mice | Rubinstein-Taybi syndrome (RTS) multilineage | [8] |
| p300 | Heterozygous mice | Embryonic lethality | [35] |
| p300 | Mice harbouring point mutation | Defects in the hematopoiesis (B-cell deficiency, megakaryocytosis, and thrombocytosis) | [39] |
| GCN5 | Mice harbouring a point mutations abrogating GN5 HAT activity | Cranial neural tube closure defects and exencephaly | [41] |
| GCN5 | Null mice | Early embryonic lethality | [40] | Knockdown zebrafish | Cardiac, fin, and limb defects | [45] |
| pCAF | Null mice | Normal phenotype in the embryo | [42, 44] | Defects in learning abilities and short-term and long-term memory in adult | [44] | Knockdown zebrafish | Cardiac, fin, and limb defects | [45] |
| ATAT-1 | Null mice | Viable, without morphological defects; loss of α-tubulin acetylation in sperm flagella; dentate gyrus distortion | [46] |
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