Stem Cells International / 2019 / Article / Tab 1 / Review Article
Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives Table 1 Bioactive molecules for skin repair and regeneration.
(a)
In vitro Initial cell Target cell Bioactive molecules Reference Pluripotent stem cells Reprogramming to keratinocyte BMP4, RA [32 , 33 ] SU6656 [17 , 42 ] Noggin, SB431542, CHIR99021 [43 ] Pluripotent stem cells Reprogramming to endothelial cells BMP4, Activin A, FGF2, VEGF-A, SB431542 [58 , 59 ] CHIR99021 [61 ā64 ] CHIR99021, VEGF-A, DLL4 [66 ] CHIR99021, FGF2, VEGF, BMP4 [68 ] Fibroblasts Reprogramming to endothelial cells 5-Aza-2 - deoxycytidine, trichostatin A, tideglusib [73 ] Pluripotent stem cells Reprogramming to hair follicle Epidermal growth factor, RA, BMP4 [83 , 84 ]
(b)
In vivo Roles of bioactive molecules Bioactive molecules Reference Regulation of the wound microenvironment Modulation of endogenous stem cell or progenitor cell Stimulation of somatic cell proliferation or repairing their function Thymosin 4 [96 , 97 ] Plerixafor, G-CSF, BIO5192 [98 , 99 ] FTY720 [100 ] 3,3 - Diindolylmethane [101 ] Tazarotene [102 ] Hydroxysafflor yellow A, deferoxamine [103 ] AES16-2M [104 ] Lithium chloride [105 ] Reducing fibrosis and treating skin diseases XAV-939 [106 ] ICG-001 [107 ] SB525334 [108 ] Bacterial cellulose decorated with DAPT-modified gold nanocomposites [109 ] STA-21 [110 ]