Review Article

Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives

Table 1

Bioactive molecules for skin repair and regeneration.
(a)

In vitro
Initial cellTarget cellBioactive moleculesReference

Pluripotent stem cellsReprogramming to keratinocyteBMP4, RA[32, 33]
SU6656[17, 42]
Noggin, SB431542, CHIR99021[43]
Pluripotent stem cellsReprogramming to endothelial cellsBMP4, Activin A, FGF2, VEGF-A, SB431542[58, 59]
CHIR99021[61ā€“64]
CHIR99021, VEGF-A, DLL4[66]
CHIR99021, FGF2, VEGF, BMP4[68]
FibroblastsReprogramming to endothelial cells5-Aza-2-deoxycytidine, trichostatin A, tideglusib[73]
Pluripotent stem cellsReprogramming to hair follicleEpidermal growth factor, RA, BMP4[83, 84]

(b)

In vivo
Roles of bioactive moleculesBioactive moleculesReference

Regulation of the wound microenvironment
Modulation of endogenous stem cell or progenitor cell
Stimulation of somatic cell proliferation or repairing their function
Thymosin 4[96, 97]
Plerixafor, G-CSF, BIO5192[98, 99]
FTY720[100]
3,3-Diindolylmethane[101]
Tazarotene[102]
Hydroxysafflor yellow A, deferoxamine[103]
AES16-2M[104]
Lithium chloride[105]
Reducing fibrosis and treating skin diseasesXAV-939[106]
ICG-001[107]
SB525334[108]
Bacterial cellulose decorated with DAPT-modified gold nanocomposites[109]
STA-21[110]