Research Article

Human Adipose-Derived Stem Cells Promote Seawater-Immersed Wound Healing by Activating Skin Stem Cells via the EGFR/MEK/ERK Pathway

Figure 4

Microscopic evaluation of wound repair after SW and hADSC treatments. HE staining for wound repair, skin thickness, and number of subcutaneous appendages (a). The regeneration of skin thickness (b) and appendages (c) in the SW group and the SW+DMEM group was significantly decreased compared to that in the control group and the SW+hADSC group. Masson’s trichrome staining of wounds in each group (d). Scale bars indicate 100 μm. , , and . The red arrow refers to a hair follicle. The frozen section immunofluorescence showed that hADSCs (CM-DIL, red) differentiated into skin stem cells (cytokeratin 19, CK19, green) to promote wound healing (e).
(a)
(b)
(c)
(d)
(e)