Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells

Figure 5

Relevant bioinformatics data and mechanistic summary of the mechanism through which Rg1 regulates the proliferation, differentiation, and migration of HSCs. (a) Venn diagram and KEGG pathway enrichment analyses revealed that the calcium signaling pathway is the key pathway through which Rg1 regulates HSC differentiation. (b) Rg1 promotes the homing of HSCs from the spleen to the bone marrow through the peripheral circulatory system in mice with myelosuppression caused by cyclophosphamide. CY: cyclophosphamide; HSC: hematopoietic stem cell; D-gal: D-galactose; CaSR: calcium-sensing receptor; MSC: mesenchymal stem cell.

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