METTL3-Mediated m<sup>6</sup>A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway

<div>Deletion of METTL3 affects C2C12 myoblast progenitor cell proliferation and differentiation. (a) Western blot detection of METTL3 expression. (b) Proliferation ability significantly decreased after METTL3 knockout determined by cell counting Kit-8 at indicated days. (c) Western blot analysis of the expression of early differentiation marker myogenin and late differentiation marker myosin in C2C12 cells. (d) Myosin staining (red) was performed 3 days later using an anti-myosin antibody, and the nuclei were counterstained with DAPI. (e) Differentiation index in the METTL3-depleted and control cells. 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Stem Cells International

fig5

Figure 5

Figure 5: METTL3-Mediated m<sup>6</sup>A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway 

Stem Cells International

METTL3-Mediated m6A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway

Figure 5

METTL3-Mediated m⁶A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway