PPARβ/δ-Interfering Peptide Enhanced Mesenchymal Stromal Cell Immunoregulatory Properties

Figure 2

Visualization of the PP11 sequence with the TF65 structure. NF-κB TF65 structures were extracted from the TF65:IRF-7:IRF-3:DNA complex (PDB #2O61) [15] (a) and from the IκBα:TF65 complex (PDB #1NFI) [14] (b). The PP11 peptide sequence situated in an accessible loop is highlighted in orange. Both 3D models were made using PyMol (c). Schematic representation of the PP11 peptide interaction mode: the PP11 peptide acts as a mimic of the NF-κB TF65 subunit and prevents PPARβ/δ interaction to the NF-κB TF65 subunit (scheme partially realized with BioRender, https://www.biorender.com).

(a)

(b)

(c)