Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner <i>In Vitro</i>

<div>Analysis of macrophage subpopulations in SK-MEL-28 tumors of xenograft mouse model treated with HUCPVC. (a–d) Representative immunostaining images of SK-MEL-28 tumor xenograft NOD SCID mouse model three weeks after animals were treated with two FTMs (FTM 1 and FTM 2), one term HUCPVC lines or HBSS as a control and quantification for the proportion of (a and b) CD68+ cells (pan-macrophage marker, sometimes associated with type 1 macrophages), (c and d) CD206+ cells (type 2 macrophage marker). Error bars represent SEM. No significant differences were observed between the groups. Scale bar = 125 <i>µ</i>m. <i>n</i> = 4, 3, 4, and 4 for control, FTM 1, FTM 2, and TERM, respectively. Insets represent twofold magnification.</div>

Stem Cells International

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Figure 2: Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner <i>In Vitro</i> 

Figure 2 | Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner In Vitro 