Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner In Vitro

Figure 5

Quantification of qdot-labeling at 24 hr (tumor, lung, and liver) and 3 weeks (tumor) following systemic injection in the NOD SCID SKMEL28 xenograft model. (a–h) Representative immunostaining images of SK-MEL-28 tumor xenograft NOD SCID mouse model three weeks after animals were treated with two FTMs (FTM 1 and FTM 2), one term HUCPVC lines or HBSS as a control and quantification for the proportion of (a and b) CD68+ cells (pan macrophage marker, sometimes associated with type 1 macrophages), and (c and d) CD206+ cells (type 2 macrophage marker). Error bars represent SEM. No significant differences were observed between the groups. Scale bar = 125 µm. n = 4, 3, 4, and 4 for control, FTM 1, FTM 2, and TERM, respectively. Insets represent twofold magnification. ; .

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