Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner In Vitro

Figure 6

Quantification of qdot label colocalization with macrophage markers in the lung (24 hr), liver (24 hr), and tumor (at 24 hr and 3 weeks). Representative immunostaining images of SK-MEL-28 tumor xenograft NOD SCID mouse model 24 hr and three weeks after animals were treated with two FTMs (FTM 1 and FTM 2), one term HUCPVC lines or HBSS as a control and quantification for the proportion of (a and b) qdot localization in tumor tissue after 24 hr (c and d) qdot localization in lung tissue after 24 hr. (e and f) qdot localization in liver tissue after 24 hr. (g and h) qdot localization in tumor tissue after 3 weeks. Error bars represent SEM. No significant differences were observed between the 24-hour groups; however, significant differences were observed between the control and FTM 1, FTM 1 and FTM 2, and FTM 1 and TERM. Scale bar = 125 µm. Insets represent twofold magnification.

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