Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker

Figure 4

(a) GO enrichment analysis of coexpressed genes. In BP, we can see those coexpressed genes were enriched in cell-substrate adhesion, extracellular matrix organisation, extracellular structure organisation, cell junction assembly, and ameboid-type cell migration. Then, in CC, the coexpressed genes were enriched in cell-substrate junction, focal adhesion, and collagen-containing extracellular matrix. At last, in MF, the coexpressed genes were enriched in cadherin-binding, actin-binding, actin filament binding, and so on. (b) KEGG enrichment analysis of coexpressed genes showed that coexpressed genes were mainly concentrated in focal adhesion, PI3K-Akt signalling pathway, regulation of actin cytoskeleton, proteoglycans in cancer, ECM-receptor interaction, MAPK signalling pathway, small cell lung cancer, and bacterial invasion of epithelial cells. (c) Protein-protein interaction network of coexpressed genes. From this network, we can see the interaction in the coexpression mode of CD73. The more lines that connect, the more interactions, which means the gene may be more important. Besides, by using the “CytoHubba” plug-in, we screened out 20 hub genes according to the MCC score.

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