[Retracted] Integrated Network Pharmacology and Gut Microbiota Study on the Mechanism of Huangqin Decoction in Treatment Diabetic Enteritis

Table 5

Target information of DE in network pharmacology.

No.	Gene names	Protein names	Uniprot ID
1	TGFB1	Transforming growth factor beta-1 proprotein [cleaved into: latency-associated peptide	P01137
2	SLC6A4	Sodium-dependent serotonin transporter	P31645
3	PTGS2	Prostaglandin G/H synthase 2	P35354
4	PTGS1	Prostaglandin G/H synthase 1	P23219
5	PRKCA	Protein kinase C alpha type	P17252
6	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	P17612
7	PON1	Serum paraoxonase/arylesterase 1	P27169
8	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736
9	OPRM1	Mu-type opioid receptor	P35372
10	JUN	Transcription factor AP-1	P05412
11	HTR2A	5-Hydroxytryptamine receptor 2A	P28223
12	HSP90AA1	Heat shock protein HSP 90-alpha	P07900
13	CASP9	Caspase-9	P55211
14	CASP8	Caspase-8	Q14790
15	CASP3	Caspase-3	P42574
16	BCL2	Apoptosis regulator Bcl-2	P10415
17	BAX	Apoptosis regulator BAX	Q07812
18	ADRB2	Beta-2 adrenergic receptor	P07550
19	NR3C2	Mineralocorticoid receptor	P08235
20	XDH	Xanthine dehydrogenase/oxidase [includes: xanthine dehydrogenase	P47989
21	VCAM1	Vascular cell adhesion protein 1	P19320
22	TNF	Tumor necrosis factor	P01375
23	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224
24	SLPI	Antileukoproteinase	P03973
25	SLC2A4	Solute carrier family 2, facilitated glucose transporter member 4	P14672
26	SELE	E-selectin	P16581
27	RELA	Transcription factor p65	Q04206
28	PRSS1	Trypsin-1	P07477
29	PPARG	Peroxisome proliferator-activated receptor gamma	Q08209
30	NOS3	Nitric oxide synthase, endothelial	P37231
31	NOS2	Nitric oxide synthase, inducible	Q14994
32	MMP1	Interstitial collagenase	O75469
33	MAPK8	Mitogen-activated protein kinase 8	P29474
34	INSR	Insulin receptor	P35228
35	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta	P03956
36	ICAM1	Intercellular adhesion molecule 1	P45983
37	HMOX1	Heme oxygenase 1	P06213
38	GSTM1	Glutathione S-transferase Mu 1	O14920
39	F7	Coagulation factor VII	P05362
40	F2	Prothrombin	P09601
41	DPP4	Dipeptidyl peptidase 4	P09488
42	CYP3A4	Cytochrome P450 3A4	P08709
43	CYP1A1	Cytochrome P450 1A1	P00734
44	CDK1	Cyclin-dependent kinase 1	P27487
45	AR	Androgen receptor	P08684
46	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P04798
47	AKT1	RAC-alpha serine/threonine-protein kinase	P06493
48	AHR	Aryl hydrocarbon receptor	P10275
49	ACHE	Acetylcholinesterase	P09917
50	ESR1	Estrogen receptor	P31749
51	IL6	Interleukin-6	P35869
52	CD14	Monocyte differentiation antigen CD14	P22303
53	FASN	Fatty acid synthase	P19793
54	TP53	Cellular tumor antigen p53	P03372
55	THBD	Thrombomodulin	P18428
56	SPP1	Osteopontin	P05231
57	SOD1	Superoxide dismutase [Cu-Zn]	P08571
58	SERPINE1	Plasminogen activator inhibitor 1	P49327
59	RUNX2	Runt-related transcription factor 2	P04637
60	RB1	Retinoblastoma-associated protein	P07204
61	RAF1	RAF protooncogene serine/threonine-protein kinase	P10451
62	PTEN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P00441
63	PRKCB	Protein kinase C beta type	P05121
64	PPARD	Peroxisome proliferator-activated receptor delta	Q13950
65	PPARA	Peroxisome proliferator-activated receptor alpha	P06400
66	PLAU	Urokinase-type plasminogen activator	P04049
67	PLAT	Tissue-type plasminogen activator	P60484
68	PARP1	Poly [ADP-ribose] polymerase 1	P05771
69	ODC1	Ornithine decarboxylase	Q03181
70	NQO1	NAD	Q07869
71	NFKBIA	NF-kappa-B inhibitor alpha	P00749
72	NFE2L2	Nuclear factor erythroid 2-related factor 2	P00750
73	NCF1	Neutrophil cytosol factor 1	P09874
74	MYC	Myc protooncogene protein	P11926
75	MPO	Myeloperoxidase	P15559
76	MMP9	Matrix metalloproteinase-9	P25963
77	MMP3	Stromelysin-1	Q16236
78	MMP2	72 kDa type IV collagenase	P01106
79	MGAM	Maltase-glucoamylase, intestinal [includes: maltase	P05164
80	MAPK1	Mitogen-activated protein kinase 1	P14780
81	IL2	Interleukin-2	P08254
82	IL1B	Interleukin-1 beta	P08253
83	IL1A	Interleukin-1 alpha	O43451
84	IL10	Interleukin-10	P28482
85	IGFBP3	Insulin-like growth factor-binding protein 3	P60568
86	IGF2	Insulin-like growth factor II	P01584
87	IFNG	Interferon gamma	P01583
88	HSPB1	Heat shock protein beta-1	P22301
89	HSPA5	Endoplasmic reticulum chaperone BiP	P17936
90	HK2	Hexokinase-2	P01344
91	HIF1A	Hypoxia-inducible factor 1-alpha	P01579
92	GJA1	Gap junction alpha-1 protein	P04792
93	FOS	Protooncogene c-Fos	P11021
94	F3	Tissue factor	P52789
95	ERBB3	Receptor tyrosine-protein kinase erbB-3	Q16665
96	ERBB2	Receptor tyrosine-protein kinase erbB-2	P17302
97	EGFR	Epidermal growth factor receptor	P01100
98	CXCL8	Interleukin-8	P13726
99	CXCL10	C-X-C motif chemokine 10	P00742
100	CTSD	Cathepsin D	P21860
101	CRP	C-reactive protein [cleaved into: C-reactive protein]	P04626
102	CLDN4	Claudin-4	P00533
103	CHEK2	Serine/threonine-protein kinase Chk2	Q01094
104	CDKN1A	Cyclin-dependent kinase inhibitor 1	P10145
105	CD40LG	CD40 ligand	P19875
106	CCND1	G1/S-specific cyclin-D1	P02778
107	CCL2	C-C motif chemokine 2	P07339
108	CAV1	Caveolin-1	P02741
109	BIRC5	Baculoviral IAP repeat-containing protein 5	P02461
110	AKR1B1	Aldo-keto reductase family 1 member B1	O96017
111	ACACA	Acetyl-CoA carboxylase 1	P38936
112	ADRB1	Beta-1 adrenergic receptor	P29965
113	ADRA2A	Alpha-2A adrenergic receptor	P24385
114	HTR2C	5-Hydroxytryptamine receptor 2C	P13500
115	DRD4	D	Q03135
116	ADRA2B	Alpha-2B adrenergic receptor	O15392
117	PDE4D	cAMP-specific 3,5-cyclic phosphodiesterase 4D	Q07817
118	KDR	Vascular endothelial growth factor receptor 2	P15121
119	HTR3A	5-Hydroxytryptamine receptor 3A	Q13085
120	CTNNB1	Catenin beta-1	P21397
121	DRD2	D	P08588
122	ESR2	Estrogen receptor beta	P35968
123	CDK2	Cyclin-dependent kinase 2	P35222
124	PTPN1	Tyrosine-protein phosphatase nonreceptor type 1	P55210
125	OLR1	Oxidized low-density lipoprotein receptor 1	P14416
126	MAPK14	Mitogen-activated protein kinase 14	P20813
127	GSK3B	Glycogen synthase kinase-3 beta	Q92731
128	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P24941
129	MT-ND6	NADH-ubiquinone oxidoreductase chain 6	P18031
130	IL4	Interleukin-4	P78380
131	STAT3	Signal transducer and activator of transcription 3	Q16539
132	CDK4	Cyclin-dependent kinase 4	P49841
133	JAK2	Tyrosine-protein kinase JAK2	Q96EB6
134	SLC2A1	Solute carrier family 2, facilitated glucose transporter member 1	P03923
135	MAPK10	Mitogen-activated protein kinase 10	P05112
136	SREBF1	Sterol regulatory element-binding protein 1	P40763
137	SOAT1	Sterol O-acyltransferase 1	P11802
138	MTTP	Microsomal triglyceride transfer protein large subunit	O60674
139	MAPK3	Mitogen-activated protein kinase 3	P11166
140	LDLR	Low-density lipoprotein receptor	P53779
141	HMGCR	3-Hydroxy-3-methylglutaryl-coenzyme A reductase	P36956
142	GSR	Glutathione reductase, mitochondrial	P55157
143	CYP19A1	Aromatase	P27361
144	BAD	Bcl2-associated agonist of cell death	P01130
145	APOB	Apolipoprotein B-100	P04035
146	ADIPOQ	Adiponectin	P00390
147	CAT	Catalase	P11511
148	UGT1A1	UDP-glucuronosyltransferase 1A1	P23141
149	HSD11B2	Corticosteroid 11-beta-dehydrogenase isozyme 2	Q92934
150	CYP2E1	Cytochrome P450 2E1	P04114
151	KCNMA1	Calcium-activated potassium channel subunit alpha-1	Q15848
152	FN1	Fibronectin	P33527
153	PRKCD	Protein kinase C delta type	P04040
154	FASLG	Tumor necrosis factor ligand superfamily member 6	P22309
155	CYCS	Cytochrome c	P05181
156	CYP2C9	Cytochrome P450 2C9	P02751