Research Article
[Retracted] miR-29c Inhibits Renal Interstitial Fibrotic Proliferative Properties through PI3K-AKT Pathway
Figure 5
A model with miR-29c implications in NRK-52E cultures. Macrophage-generated TGF-β1 inhibits the miR-29c expression and consequently activates the PI3K-Akt pathway, which then increases the Col-1 expression, which reconstructs the matrix and promotes the culture proliferation in RIF. Such a process plays a crucial part in the etiology of renal fibrosis and miR-29c suppresses this process.