Review Article

[Retracted] Advances in the Study of Inhaled Formulations for the Treatment of Pulmonary Arterial Hypertension

Table 1

The inhalation drugs and their function to treat PAH.

Inhalation drugsFunction

Prostacyclin analoguesStabilize role in maintaining the system of the intravascular environment
Nitric oxideInhibit platelet aggregation, smooth muscle cell proliferation
Soluble guanylate cyclase (sGC) agonistCatalyze the formation of cGMP
PDE inhibitorsRegulate their hydrolysis in the cell
Rho kinase inhibitorsMediate a series of phosphorylation reactions of their downstream effectors
Vasoactive intestinal peptideDiastole smooth muscle cells and antiproliferative effects
AdrenomedullinInhibit smooth muscle proliferation and migration