Genomic Designs of rAAVs Contribute to Pathological Changes in the Livers and Spleens of Mice

Figure 3

Liver weights vary while spleen weights trend heavier in rAAV-injected C57BL/6 Mice. (a) Endpoint liver weights of C57 mice. ANOVA . (b) Endpoint spleen weights. ANOVA . for all groups except CB-PolyA (). (c) Liver : spleen weight ratios of C57BL/6 mice injected with rAAVs. Ratios reflect variability of the organs’ weights but are all similar. Kruskal-Wallis . (d, e) Clot times via APTT of C57BL/6 mice injected with various rAAVs at day 90 and 194 postinjection. for CB-PolyA, for all other groups. ANOVA tests performed for (d) and (e).

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