Intravitreally Administered Soluble VEGF Receptor-1 Variant Tested as a Potential Gene Therapeutic for Diabetic Retinopathy

Figure 4

Retinal vascular permeability is reduced by rAAV2-sVEGFRv-1. Linked to retinal vasodegeneration and the subsequent development of DR-related vision loss, vascular leakage is observable in retinal flat mounts (a, left column) as blurred regions of FITC-dextran staining, with the details becoming more distinguishable at 100x magnification (a, right column). The quantification of leaky vessel formation was determined () as a ratio relative to normal control mice (b). Scale bar: 50 μm; vs. sham.

(a)

(b)