The Association between Genetic Variants and Gene Expression in RAAS Genes Using Captive-Bred Vervet Monkeys (Chlorocebus aethiops)

Table 2

Sequence variants identified in the colony of captive-bred Vervet monkeys (Chlorocebus aethiops).

Gene	Exon	Nucleotide change	Type of change	AA change	Type of mutation	MutationTaster	PolyPhen-2	SIFT	VEP
AGT	Exon 2	C195>T	Transition	P65P	Silent	Polymorphism	ND	Neutral	Silent variant
		A228>G	Transition	T76T	Silent	Polymorphism	ND	Neutral	Silent variant
		T266>C	Transition	V89A	Missense	Polymorphism	Benign	Neutral	Missense variant
	Exon 3	C954>A	Transversion	T318T	Silent	Polymorphism	ND	Neutral	Silent variant
	Exon 5	C1431>T	Transition	R477R	Silent	Disease-causing	ND	Neutral	Silent variant
CYP3A5	Exon 5	G373>C	Transversion	E125Q	SNPs	Polymorphism	PD	Neutral	Missense variant
	Exon 10	G885>T	Transversion	L295L	Silent	Disease-causing	ND	ND	Silent variant
		G888>A	Transition	V296V	Silent	ND	ND	ND	Silent variant
GRK4	Exon 3	G305>T	Transversion	L102R	SNP	Polymorphism	Benign	Neutral	Missense variant
	Exon 5	C533>T	Transition	A178V	SNP	Polymorphism	Benign	Neutral	Missense variant
	Exon 6	A587>G	Transition	Q196R	SNP	ND	Benign	ND	Missense variant
		G588>C	Transversion	Q196R	SNP	ND	Benign	ND	Missense variant
	Exon 11	G1241>A	Transition	S414N	SNP	Disease-causing	Benign	Deleterious	Missense variant
SLC4A5	Exon 6	A183>G	Transition	S61S	Silent	Polymorphism	ND	Neutral	Silent variant
	Exon 8	G540>T	Transversion	T180T	Silent	Disease-causing	ND	Neutral	Silent variant
	Exon 9	C705>T	Transition	R235R	Silent	Disease-causing		Neutral	Silent variant
	Exon 17	G1740>A	Transition	S580S	Silent	Disease-causing	ND	Neutral	Silent variant
	Exon 18	C>1944T	Transition	G648G	Silent	ND	ND	ND	Silent variant
		G1947>C	Transversion	L649F	SNPs	ND	Benign	Neutral	Modifier
	Exon 24	C2817>T	Transition	T939T	Silent	Disease-causing	ND	Neutral	Modifier
	Exon 25	G2892>A	Transition	V964V	Silent	ND	ND	Neutral	ND

AA: amino acids; PD: possibly damaging; ND: not determined; SNP: single nucleotide polymorphism; SIFT: Sorting Intolerant from Tolerant; VEP: Variant Effect Predictor.