Intratumoral CD3+ T-Lymphocytes Immunoexpression and Its Association with c-Kit, Angiogenesis, and Overall Survival in Malignant Canine Mammary Tumors

Table 2

Association between considered molecular markers groups and overall survival.

Molecular markers			Overall survival Univariate; (mean values)		Overall survival Multivariate; (hazard ratio)
CD3/c-kit	Low CD3/low c-kit	22	699.154	0.002	—	NS
	Low CD3/high c-kit or high CD3/low c-kit	35	500.809
	High CD3/high c-kit	23	335.083
CD3/VEGF	Low CD3/low VEGF	20	696.583	0.006	—	NS
	Low CD3/high VEGF or high CD3/low VEGF	35	524.480
	High CD3/high VEGF	25	383.500
c-kit/VEGF	Low c-kit/low VEGF	12	663.167	<0.0001	6.102	0.010
	Low c-kit/high VEGF or high c-kit/low VEGF	26	697.143
	High c-kit/high VEGF	42	371.462

, number of samples; , statistical significance; NS, not significant; Cox proportional hazard model: forward stepwise method-likelihood ratio.