High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients

Figure 1

Immunohistochemically visualized expression of ADAM-10 in cutaneous melanoma. Lack of ADAM-10 immunoreactivity in normal skin ((a), 200x, hematoxylin). Low percentage of ADAM-10-positve cells in cutaneous melanoma with brisk tumor-infiltrating lymphocytes ((b), 10% of ADAM-10 positive cells, 200x; (c), hematoxylin, 30% of ADAM-10 positive cells, 200x, hematoxylin). Intermediate percentage of ADAM-10 positive cells in cutaneous melanoma with nonbrisk tumor-infiltrating lymphocytes ((d), 40% of ADAM-10 positive cells, 400x). Enhanced ADAM-10 immunoreactivity in melanoma cells with scanty tumor-infiltrating lymphocytes ((e), IRS 12, 400x, hematoxylin). High cytoplasmic reactivity of ADAM-10 in regional lymph node metastases ((f), 200x, hematoxylin).

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