High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients

Table 3

Correlations between clinicopathological and histopathological characteristics and ADAM-10 expression parameters in primary tumors and nodal metastases.

	ADAM-10 expression, primary tumor			ADAM-10 expression, nodal metastasis
Clinicopathological parameters	%	Int	IRS	%	Int	IRS
pT^a	0.965	0.292	0.437	0.528	0.424	0.424
pN^b	0.195	0.757	0.820	0.262	0.273	0.477
Distant metastases^b	0.292	0.088	0.204	0.482	0.673	0.934
Recurrence^b	0.633	0.952	0.989	0.390	0.092	0.243
Age^a	0.785	0.145	0.029	0.043	0.037	0.037
Gender^b	0.305	0.953	0.952	0.696	0.574	0.740
Primary tumor location^c	0.213	0.180	0.424	0.825	0.546	0.447
Clinicopathological parameters	%	Int	IRS	%	Int	IRS
Breslow thickness^a	0.640	0.265	0.363	0.558	0.420	0.394
Clark level^a	0.229	0.945	0.899	0.785	0.466	0.909
Growth phase^b	0.614	0.264	0.220	100% vertical growth phase
Histologic type^c	0.462	0.299	0.160	0.390	0.500	0.342
Mitotic rate^a	0.319	0.367	0.552	0.845	0.140	0.248
Ulceration^b	0.367	0.603	0.582	0.720	0.847	0.800
Lymphangio invasion^b	0.290	0.531	0.485	0.631	0.205	0.212
Microsatellitosis^b	0.398	0.275	0.551	0.631	0.300	0.307
Tumor-infiltrating lymphocytes (TILs)^c	0.037	0.459	0.775	0.987	0.105	0.256
Tumor regression^b	0.597	0.073	0.228	100% without regression

value of Spearman rank correlation.
value of Mann-Whitney test.
value of Kruskal-Wallis test.
Statistically significant results () are in bold font.