High Percentage of ADAM-10 Positive Melanoma Cells Correlates with Paucity of Tumor-Infiltrating Lymphocytes but Does Not Predict Prognosis in Cutaneous Melanoma Patients

Table 4

Correlations between ADAM-10 expression parameters in primary tumors and nodal metastases and SPARC and N-cadherin immunoreactivity in melanoma cells in primary tumors and nodal metastases.

Expression of; ADAM-10	Expression of SPARC in primary tumor			Expression of SPARC in nodal metastasis			Expression of; N-cadherin in primary tumor			Expression of; N-cadherin in nodal metastasis
	%^a	Int^b	IRS^c	%	Int	IRS	%	Int	IRS	%	Int	IRS
Primary tumor
%	0.006	0.197	0.027	0.190	0.128	0.135	0.120	0.364	0.109	0.095	0.335	0.198
Int	<0.001	<0.001	<0.001	0.100	0.101	0.064	<0.001	<0.001	<0.001	0.029	0.015	0.015
IRS	<0.001	<0.001	<0.001	0.010	0.041	0.007	<0.001	<0.001	<0.001	<0.001	0.003	<0.001
Nodal metastasis
%	0.193	0.149	0.128	0.001	0.066	0.004	0.393	0.060	0.212	0.004	0.024	0.004
Int	0.107	0.279	0.124	<0.001	<0.001	<0.001	0.288	0.052	0.110	0.022	0.001	0.002
IRS	0.080	0.084	0.041	<0.001	<0.001	<0.001	0.325	0.012	0.058	0.001	<0.001	<0.001

Percentage of protein-positive melanoma cells (0–4 points).
^bIntensity of immunohistochemical reaction (0–3 points).
^cImmunoReactive Score (product of the scores for the percentage of positive cells and intensity of reaction (0–12 points)).
P value of Spearman rank correlation; statistically significant results () are in bold font.