Analytical Cellular Pathology

Research Article

Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs

Table 1

T/NT of  131I-antiAFPMcAb-GCV-BSA-NPs and  131I in nude mice with transplanted hepatoma (mean ± SD, ).
Time4 h12 h24 h48 h
Groups131I-antiAFP-GCV-BSA-NPs131I 131I-antiAFP-GCV-BSA-NPs131I 131I-antiAFP-GCV-BSA-NPs131I131I-antiAFP-GCV-BSA-NPs131I
Heart 1.26 ± 0.0411.12 ± 0.142.26 ± 0.1721.16 ± 0.074.16 ± 0.2131.30 ± 0.218.77 ± 0.1941.65 ± 0.26
Liver0.46 ± 0.0450.35 ± 0.040.86 ± 0.0660.39 ± 0.091.36 ± 0.1670.41 ± 0.022.35 ± 0.4080.46 ± 0.06
Spleen1.02 ± 0.0690.91 ± 0.051.78 ± 0.06100.97 ± 0.123.08 ± 0.16111.14 ± 0.129.02 ± 1.42121.57 ± 0.12
Lung1.19 ± 0.04131.07 ± 0.142.26 ± 0.20141.18 ± 0.244.65 ± 0.52151.29 ± 0.109.38 ± 2.21161.90 ± 0.60
Kidney0.64 ± 0.030.56 ± 0.101.29 ± 0.07170.66 ± 0.172.31 ± 0.08180.77 ± 0.105.91 ± 0.29190.99 ± 0.21
Stomach1.22 ± 0.11200.98 ± 0.112.37 ± 0.03211.18 ± 0.065.11 ± 0.45221.53 ± 0.289.75 ± 1.80231.99 ± 0.24
Intestine1.58 ± 0.08241.25 ± 0.173.04 ± 0.03251.40 ± 0.187.44 ± 1.01262.07 ± 0.1612.29 ± 0.56272.45 ± 0.45
Brain3.85 ± 0.19282.58 ± 0.418.76 ± 0.20293.28 ± 0.8215.67 ± 2.10303.42 ± 0.3630.68 ± 5.36313.32 ± 0.41
Bone0.97 ± 0.050.89 ± 0.122.24 ± 0.15321.00 ± 0.294.22 ± 0.15331.24 ± 0.067.05 ± 0.42341.52 ± 0.42
Muscle1.16 ± 0.041.08 ± 0.042.74 ± 0.21351.34 ± 0.205.65 ± 0.57361.74 ± 0.2110.88 ± 0.53372.09 ± 0.36
Blood0.18 ± 0.010.15 ± 0.010.40 ± 0.03380.19 ± 0.030.66 ± 0.03390.22 ± 0.041.70 ± 0.12400.33 ± 0.08
⁢ versus the heart group of 4 h 131I; versus the heart group of 12 h 131I; versus the heart group of 24 h 131I; versus the heart group of 48 h 131I; versus the liver group of 4 h 131I; versus the liver group of 12 h 131I; versus the liver group of 24 h 131I; versus the liver group of 48 h 131I; versus the spleen group of 4 h 131I; versus the spleen group of 12 h 131I; versus the spleen group of 24 h 131I; versus the spleen group of 48 h 131I; versus the lung group of 4 h 131I; versus the lung group of 12 h 131I; versus the lung group of 24 h 131I; versus the lung group of 48 h 131I; versus the kidney group of 12 h 131I; versus the kidney group of 24 h 131I; versus the kidney group of 48 h 131I; versus the stomach group of 4 h 131I; versus the stomach group of 12 h 131I; versus the stomach group of 24 h 131I; versus the stomach group of 48 h 131I; versus the intestine group of 4 h 131I; versus the intestine group of 12 h 131I; versus the intestine group of 24 h 131I; versus the intestine group of 48 h 131I; versus the brain group of 4 h 131I; versus the brain group of 12 h 131I; versus the brain group of 24 h 131I; versus the brain group of 48 h 131I; versus the bone group of 12 h 131I; versus the bone group of 24 h 131I; versus the bone group of 48 h 131I; versus the muscle group of 12 h 131I; versus the muscle group of 24 h 131I; versus the muscle group of 48 h 131I; versus the blood group of 12 h 131I; versus the blood group of 24 h 131I; versus the blood group of 48 h 131I.