Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics

Table 2

Median DNA (range) from 18- versus 20-gauge needle samples from normal and tumor tissues obtained from the kidney, lung, and liver.

	18G biopsy (ng DNA)	20G biopsy (ng DNA)	value (18G vs. 20G)
Any organ
Normal	4350 (1730, 13040)	1970 (700, 5620)	<0.001
Tumor	5880 (1060, 13390)	2710 (370, 6280)	<0.001
Kidney
Normal	4150 (1930, 11890)	1360 (700, 3870)	<0.001
Tumor	3170 (1180, 13390)	1450 (370, 4600)	<0.001
value (normal vs. tumor)	1.00	0.890
Lung
Normal	3240 (1740, 13040)	1720 (760, 3520)	<0.001
Tumor	6910 (3070, 12570)	3350 (1110, 6280)	<0.001
value (normal vs. tumor)	<0.001	<0.001
Liver
Normal	6050 (3790, 9740)	2480 (1890, 5620)	<0.001
Tumor	6190 (1060, 11530)	2630 (480, 5160)	<0.001
value (normal vs. tumor)	0.804	0.847