Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics

Table 3

Median RNA (range) from 18- versus 20-gauge needle samples from normal and tumor tissues obtained from the kidney, lung, and liver.

	18G biopsy (ng RNA)	20G biopsy (ng RNA)	value (18G vs. 20G)
Any organ
Normal	510 (30, 23540)	240 (30, 7090)	<0.001
Tumor	1100 (110, 17210)	230 (60, 5210)	<0.001^a
Kidney
Normal	480 (230, 1210)	270 (110, 460)	<0.001
Tumor	510 (220, 3420)	290 (70, 2480)	<0.001
value (normal vs. tumor)	0.855	0.217
Lung
Normal	150 (30, 4940)	120 (30, 400)	0.008
Tumor	2870 (170, 12700)	290 (70, 2480)	<0.001
value (normal vs. tumor)	<0.001	<0.001
Liver
Normal	4740 (60, 23540)	700 (60, 7090)	<0.001
Tumor	1190 (110, 17210)	150 (60, 5210)	<0.001
value (normal vs. tumor)	0.012	0.002

^aExact test could not be performed due to ties, normal approximation used.