The Role of Abnormal Methylation of Wnt5a Gene Promoter Regions in Human Epithelial Ovarian Cancer: A Clinical and Experimental Study

Table 1

Relationship between Wnt5a immunohistochemistry and methylation with clinicopathologic features of ovarian carcinoma.

Clinicopathologic parameters		Protein expression		Methylation positive
Age (years)
≤48	34	14 (41.18)	>0.05	13 (38.24)
>48	45	21 (46.47)		18 (40)	>0.05
WHO grades
G1	13	10 (76.92)	0.005	5 (38.46)
G2	29	13 (44.83)		10 (34.48)	>0.05
G3	37	12 (32.43)		16 (43.24)
FIGO stages
I~II	36	22 (61.11)	0.006	9 (25)
III~IV	43	13 (30.23)		22 (51.16)	0.018
Histological types
Serous adenocarcinoma	50	22 (44)	>0.05	19 (38)
Mucinous adenocarcinoma	23	11 (47.83)		9 (39.13)	>0.05
Others	6	3 (50)		2 (33.33)
Lymph node metastasis
No	38	20 (52.63)	0.037	10 (26.32)	0.024
Yes	41	15 (36.59)		21 (51.22)

The value of G1 compared with that of G3.