Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Table 2

Correlation between FOLR1, DHFR, and MTRR expression and clinicopathological parameters.

Parameters		Total	FOLR expression		DHFR expression		MTRR expression
Histology	Epithelial	61		0.001		0.543		0.001
	Other	19
FIGO Stage	I-II	37		0.004		0.360		0.036
	III-IV	43
Grade	G1	30		0.006		0.123		0.033
	G2-G3	50
Node status	Positive	23		0.026		0.149		0.048
	Negative	57
Omentum metastasis	Yes	28		0.584		0.044		0.734
	No	52
Organ metastasis	Yes	20		0.015		0.169		0.032
	No	60
Ascites	≥500 ml	30		0.367		0.087		0.227
	<500 ml	50
Platinum resistance	Resistant	28		0.004		0.014		0.015
	Sensitive	52
Outcome	CR	27		0.001		0.032		0.047
	PR	25
	SD	12
	PD	16

Notes: : metastasis to any one of liver, lung, brain and spleen.