Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Table 3

Performance of FOLR1, DHFR, and MTRR in the differential diagnosis drug-resistant cases from ovarian cancer patients.

Groups	Sensitivity	Specificity	Accurate	Youden index	True positive	True negative	False positive	Flase negative
FOLR1	88.2%	55.2%	76.2%	43.4%	45	16	13	6
DHFR	69.0%	62.7%	65.0%	31.7%	20	32	19	9
MTRR	44.8%	92.2%	75.0%	37.0%	13	47	4	16
FOLR1+DHFR+MTRR	82.1%	84.6%	83.8%	66.8%	23	44	8	5