Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice

Figure 6

Membranous CD34 expression the mucosal cryptal epithelium and cytoplasmic expression in macrophages, fibroblasts, and mast cells in the lamina propria of the colon. (a) Negative expression (sum score 0) in mice of the control negative group. (b) Negative membranous expression in the mucosal cryptal epithelium and moderate cytoplasmic expression in macrophages, fibroblasts, and mast cells of colonic lamina propria (sum score 1) in the control positive group. (c) Weak-moderate expression in both mucosal crypts and lamina propria (sum score 3) in mice of group 3 (DSS exposure & 6-TG treatment). (d) Weak expression in both mucosal crypts and lamina propria (sum score 2) in mice of group 4 (DSS exposure &10 mg/kg b.w. Shogaol treatment). (e) and (f) Moderate-strong expression in both mucosal crypts and lamina propria (sum score 6) in mice of group 5 (DSS exposure & 20 mg/kg b.w. Shogaol treatment) and group 6 (DSS exposure and 40 mg/kg b.w. Shogaol treatment).

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