In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers

<div>Workflow and multiplexed labeling strategy of this study. (a) Proteomic workflow of this study. (b) Labeling strategy applied in this study: peptides were labeled with TMT 10plex reagents. All tissue samples were split into three labeling batches (group 1/2/3). First, the pooled reference sample was generated by pooling aliquots of each individual sample from all patients, which was further assigned in the TMT labeling experiment as the reference channel. The 9 serial samples (T for tumor, M for metastasis, and N for normal colon) and the reference sample were together included in one TMT labeling experiment group, and there are 3 groups in total.</div>

Analytical Cellular Pathology

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Figure 1

Figure 1: In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers 

Figure 1 | In-Depth Characterization of Mass Spectrometry-Based Proteomic Profiles Revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers 