Destruction of the Dorsal Motor Nucleus of the Vagus Aggravates Inflammation and Injury from Acid-Induced Acute Esophagitis in a Rat Model

Figure 5

DMV destruction downregulated c-fos expression in the PVN and the NTS/DMV. (a) c-fos-positive cells with red nuclei in the PVN in the different groups. (×400). (b) Induction of c-fos expression in the PVN by esophageal instillation and DMV destruction. c-fos expression in the PVN increased more significantly in the sham + acid group than in the sham + saline group (). After DMV destruction, c-fos expression more significantly decreased in the PVN in the operation + saline group than in the sham + acid group (). c-fos expression was higher in the PVN in the operation + acid group than in the operation + saline group (). (c) c-fos-positive cells with red nuclei in the NTS/DMV in the different groups (×400). (d) Induction of c-fos expression in the NTS/DMV by esophageal instillation and DMV destruction. c-fos expression in the NTS/DMV increased more in the sham + acid group than in the sham + saline group (). After DMV destruction, c-fos expression more significantly decreased in the NTS/DMV in the operation + saline group than in the sham + acid group (). c-fos expression was higher in the NTS/DMV in the operation + acid group than in the operation + saline group () (Con: control group; S+S: sham + saline group; S+A: sham + acid group; O+S: operation + saline group; O+A: operation + acid group. , , , ).

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