ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

<div>Effect of ABCG1 on H<sub>2</sub>O<sub>2</sub>-induced NADPH oxidase activity in HUAECs. HUAECs were transfected with the specific ABCG1 siRNA or ABCG1 overexpression plasmid or preincubated with T0901317 and then treated with H<sub>2</sub>O<sub>2</sub> for 12 h or not. At the end of the incubation, NADPH oxidase activity was detected by (a) lucigenin-derived chemiluminescence and by translocation of cytosolic p47phox to the membrane via (b, c) western blotting. 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Analytical Cellular Pathology

fig2

Figure 2

Figure 2: ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 

Figure 2 | ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 