ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

<div>Effect of ABCG1 on H<sub>2</sub>O<sub>2</sub>-induced expression of Nox4 in HUAECs. HUAECs were transfected with the specific ABCG1 siRNA or ABCG1 overexpression plasmid or preincubated with T0901317 and then treated with H<sub>2</sub>O<sub>2</sub> or not. At the end of the incubation, the expressions of Nox4 (a) mRNA and (b) protein were measured by real-time PCR and western blotting, respectively. 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d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. HUAECs incubated with H<sub>2</sub>O<sub>2</sub>.</div>

Analytical Cellular Pathology

fig3

Figure 3

Figure 3: ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 

Figure 3 | ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 