ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells

<div>Effect of ABCG1 on antioxidative Nrf2/HO-1 signals in HUAECs treated with H<sub>2</sub>O<sub>2</sub>. HUAECs were transfected with the specific ABCG1 siRNA or ABCG1 overexpression plasmid or preincubated with T0901317 and then treated with H<sub>2</sub>O<sub>2</sub> or not. (a, b) Antioxidant HO-1 protein expression and (c, d) Nrf2 expression in both the cytoplasm and nucleus were measured by western blotting. (e) Nrf2 expression was inhibited by Nrf2 siRNA under the condition of ABCG1 overexpression. 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Analytical Cellular Pathology

fig4

Figure 4

Figure 4: ABCG1 Attenuates Oxidative Stress Induced by H<sub>2</sub>O<sub>2</sub> through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 

Figure 4 | ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells 