p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1

Figure 1

Knockdown of HNRNPA1 attenuated the proliferation, invasion, and migration of HeLa cells. (a) Western blot results showed the expression of HNRNPA1 in normal cervical epithelial cells (HCerEPiC) and HPV-associated cervical cancer cells (HeLa cells, Caski cells, and SiHa cells). The relative intensities of HNRNPA1/GAPDH were quantified using ImageJ. ; . (b) HNRNPA1 expression was measured by western blot in HeLa cells stably expressing nontargeting control (siCon) and siHNRNPA1. The relative intensities of HNRNPA1/GAPDH were quantified using ImageJ. . (c) Effects of HNRNPA1 on HeLa cell proliferation were determined by CCK-8 kits. . (d) Transwell assay was performed to determine the invasion and migration of HeLa cells. The invasion and migration of HeLa cells were quantified using Image-Pro Plus 6.0. ; .

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