Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining

Table 1

Tumor budding in comparison to clinicopathological parameters.

		Budding H&E					Sig	Budding by IHC					Sig
		No/mild budding		Moderate/marked budding				No/mild budding		Moderate/marked budding
			%		%				%		%
Site	Glottic	53	63.1%	0	0.0%	0.0001	HS	53	81.5%	0	0.0%	0.0001	HS
	Supraglottic	31	36.9%	10	29.4%			12	18.5%	29	54.7%
	Transglottic	0	0.0%	17	50.0%			0	0.0%	17	32.1%
	Subglottic	0	0.0%	7	20.6%			0	0.0%	7	13.2%
Grade	Grade I	46	54.8%	0	0.0%	0.0001	HS	46	70.8%	0	0.0%	0.0001	HS
	Grade II	38	45.2%	7	20.6%			19	29.2%	26	49.1%
	Grade III	0	0.0%	27	79.4%			0	0.0%	27	50.9%
Stage	Stage I	2	2.4%	0	0.0%	0.0001	HS	2	3.1%	0	0.0%	0.0001	HS
	Stage II	9	10.7%	0	0.0%			9	13.8%	0	0.0%
	Stage III	52	61.9%	0	0.0%			52	80.0%	0	0.0%
	Stage IV	21	25.0%	34	100.0%			2	3.1%	53	100%
Node stage	N0	55	65.5%	0	0.0%	0.0001	HS	55	84.6%	0	0.0%	0.0001	HS
	N1	22	26.2%	2	5.9%			10	15.4%	14	26.4%
	N2/3	7	8.3%	32	94.1%			0	0.0%	39	73.6%
Pericapsular invasion	Absent	84	100.0%	3	8.8%	0.0001	HS	65	100.0%	22	41.5%	0.0001	HS
	Present	0	0.0%	31	91.2%			0	0.0%	31	58.5%
Vascular invasion	Absent	84	100.0%	12	35.3%	0.0001	HS	65	100.0%	31	58.5%	0.0001	HS
	Present	0	0.0%	22	64.7%			0	0.0%	22	41.5%

Chi-square tests; Fisher’s exact test.