TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma

Figure 1

Autophagy was positively correlated with thyroid cancer progression. Gene set enrichment analysis (GSEA) showed that the expression of genes involved in autophagy and lysosome-related biological functions was upregulated in thyroid cancer. (a) GSEA of the data revealed that human thyroid cancer specimens have elevated expression of autophagy-lysosome genes compared with normal thyroid tissue. NES: normalized enrichment score; Nom.: nominal. (b) GSEA showing the correlation between thyroid cancer and the macroautophagy gene signature. (c) Upregulation of macroautophagy genes in thyroid cancer relative to matched normal tissue. (d) GSEA showing the correlation between thyroid cancer and the lysosome gene signature. (e) Upregulation of lysosome genes in thyroid cancer relative to matched normal tissue. (f, g) Immunohistochemistry assays showed an increase in P62/SQSTM1 and LC3 expression in thyroid cancer tissues compared with normal tissues.

(a)

(b)

(c)

(d)

(e)

(f)

(g)