Research Article

Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis

Figure 2

miR-19a is upregulated in the hypoxia-exposed CRC cells: (a) differentially expressed miRNAs between CRC cells cultured under hypoxic and normoxic conditions screened using a microarray analysis; (b) expression of miR-19a in HCT116 and SW480 cells cultured under hypoxic and normoxic conditions validated by RT-qPCR (, two-way ANOVA); (c) expression of miR-19a in cancer and paracancerous tissues from CRC patients examined by RT-qPCR (, paired -test); (d) relevance of miR-19a expression to the survival of patients (, Kaplan-Meier analysis); (e) relevance of miR-19a expression to the clinical characteristics of patients; (f) expression of miR-19a in HCT116 and SW480 and in normal NCM460 cells determined by RT-qPCR (, one-way ANOVA). Data were presented as the from three independent experiments.
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