Research Article
Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis
Figure 6
Hypoxia induces the STAT3/miR-19a/PTEN axis to affect activity of the CRC cells: (a) proliferation and viability of cells examined by the CCK-8 assay (#&, two-way ANOVA); (b, c) migration (b) and invasion (c) of cells examined by Transwell assays (#&, two-way ANOVA); (d) protein levels of E-cadherin and Vimentin in HCT116 and SW480 cells examined by western blot analysis (#&, two-way ANOVA). Data were presented as the from three independent experiments. Compared to the hypoxia + STAT3-NC group; #compared to the si-STAT3 + miR-19a control group; &compared to the miR-19a mimic + PTEN-NC group.
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