Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells

<div>OGD/R inhibits SH-SY5Y cell growth, downregulates miR-1287-5p expression, and upregulates LONP2 expression. (a) CCK-8 assay was performed to assess the viability of OGD/R-induced SH-SY5Y cells. Flow cytometry was performed to detect (b) apoptosis, (c) ROS production, and (d) mitochondrial membrane potential in OGD/R-induced SH-SY5Y cells. (e) qRT-PCR was performed to detect miR-1287-5p expression in OGD/R-induced SH-SY5Y cells. (f) Western blot was performed to detect LONP2 expression in OGD/R-induced SH-SY5Y cells. 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Analytical Cellular Pathology

fig2

Figure 2

Figure 2: Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells 