GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in Colorectal Cancer

Table 2

Prognostic factors for overall survival in CRC patients obtained from univariate/multivariate analysis.

Item	Univariate analysis		Multivariate analysis
	HR (95% CI)		HR (95% CI)
Gender (male, female)	1.362 (2.498-0.743)	0.318	NA
Age (>60 years, ≤60 years)	1.099 (2.040-0.592)	0.764	NA
Tumor size (≥5 cm, <5 cm)	0.868 (1.581-0.477)	0.644	NA
Differentiation (poor, high-middle)	1.528 (3.297-0.709)	0.279	NA
TNM stage (III-IV, I-II)	3.375 (6.588-1.729)	<0.001	5.981 (19.655-1.820)	0.003
Depth of invasion (T3-4, T1-2)	2.734 (6.482-1.153)	0.022	1.579 (3.947-0.632)	0.328
Lymph node metastasis (yes, no)	2.430 (4.516-1.307)	0.005	0.349 (1.019-0.119)	0.054
GRHL3 (high, low or no)	3.897 (8.772-1.731)	0.001	3.029 (6.979-1.315)	0.009