Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma

<div>Inhibition of cell autophagy reduces the promoting effect of LMP1 on the lymphoma cell resistance to DDP. The autophagy inhibitor 3-MA was added to the KHYG-1 cells overexpressing LMP1, and the autophagy activator rapamycin was added to the SNK-6 cells poorly expressing LMP1. (a) The autophagy level was observed by MDC staining. (b) The IC50 value of KHYG-1 and SNK-6 cells to DDP measured by the CCK-8 kit. (c) Cell proliferation was detected by colony formation assay. (d) The cytotoxicity of DDP to the KHYG-1 and SNK-6 cells tested by LDH kit. 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test are used to test the significant difference of data. 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Analytical Cellular Pathology

fig3

Figure 3

Figure 3: Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma 

Figure 3 | Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma 