The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia

<div>The relation of oxidative stress and autophagy in microglia. The ROS level, autophagy-related proteins, and autophagolysosomes were measured in microglia and OGD/R-induced microglia, and the autophagy inhibitor 3MA and autophagy agonist RAPA were involved. (a, b) ROS level was detected using flow cytometry. (c) Autophagy-related proteins were detected using western blotting including Atg5 (d), LC3I/II (e), and Beclin-1 (f). (g) Autophagolysosomes (red arrow) were observed using transmission electron microscope. 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Analytical Cellular Pathology

fig1

Figure 1

Figure 1: The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia 