MicroRNA-520a Suppresses Pathogenesis and Progression of Non-Small-Cell Lung Cancer through Targeting the RRM2/Wnt Axis

Figure 1

miR-520a is poorly expressed in NSCLC tissues and cells. (a) NSCLC tissues and the adjacent normal tissues observed by HE staining. (b) Differentially expressed miRNAs between cancer and the adjacent normal tissues screened out by miRNA microarray analysis. (c) The miR-520a expression in NSCLC and the adjacent normal tissues determined by RT-qPCR (, two-way ANOVA). (d) Overall survival rate of patients with different levels of miR-520a according to a 3-year followed-up study. (e) The miR-520a expression in NSCLC cell lines and in normal pulmonary epithelial cell line 16HBE determined by RT-qPCR (, one-way ANOVA). (f) The miR-520a expression in A549 and H460 cells after miR-520a mimic/control transfection determined by RT-qPCR (, two-way ANOVA). (g) The expression of miR-520a in NSCLC predicted on the TCGA database. (h) Relevance of miR-520a to the survival of patients predicted on the TCGA database.

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