XBP1 Regulates the Transcription of HIF-1a in BALB/c Mice with Chronic Rhinosinusitis without Polyps

Figure 1

XBP1 is highly expressed in CRSsNP patients and CRSsNP mice. (a) Highly expressed XBP1 in CRSsNP screened using the GSE69093 dataset. (b) Analysis of differentially expressed genes of in the GSE194282 dataset. (c) RT-qPCR analysis of XBP1 expression in collected nasal mucosal tissue samples from CRSsNP patients and controls. (d) The levels of inflammatory factors IFN-γ, IL-1β, and IL-6 in nasal mucosal tissues of patients with CRSsNP and controls measured using ELISA. (e) The levels of inflammatory factors IL-4 and IL-13 in nasal mucosal tissues of patients with CRSsNP and controls measured using ELISA. (f) RT-qPCR analysis of XBP1 expression in nasal mucosal tissue samples from CRSsNP mice and controls. (g) Mucin expression in nasal mucosal epithelial cells of CRSsNP mice and controls examined using PAS staining. (h) Pathological changes of nasal mucosa in mice with CRSsNP and controls observed by HE staining. (i) The levels of inflammatory factors IFN-γ, IL-1β, and IL-6 in nasal mucosal tissues of mice with CRSsNP and controls measured using ELISA. (j) The levels of inflammatory factors IL-4 and IL-13 in nasal mucosal tissues of mice with CRSsNP and controls measured using ELISA. versus the control participants or mice. The data are measurement data, presented as . Data between two groups were compared using an unpaired test. The experiment was independently repeated three times. .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)