XBP1 Regulates the Transcription of HIF-1a in BALB/c Mice with Chronic Rhinosinusitis without Polyps

Figure 2

XBP1 knockdown alleviates the development of CRSsNP in mice. (a, b) Detection of mRNA and protein expression of XBP1 in nasal mucosa tissues of mice after downregulation of XBP1 by (a) RT-qPCR and (b) Western blot. (c) PAS staining analysis of mucin expression in nasal mucosal epithelial cells of mice. (d) Pathological changes of nasal mucosa in mice observed by HE staining. (e) The levels of inflammatory factors IFN-γ, IL-1β, and IL-6 in nasal mucosal tissues of mice measured using ELISA. (f) The levels of inflammatory factors IL-4 and IL-13 in nasal mucosal tissues of mice measured using ELISA. and versus the CRSsNP mice administrated with sh-NC. The data are measurement data, presented as . Data between two groups were compared using an unpaired test. The experiment was independently repeated three times. .

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